NexGard COMBO is a spot-on solution for cats. The active ingredients are esafoxolaner (an ectoparasiticide of the isoxazoline family), eprinomectin (an endectocide of the macrocyclic lactone class) and praziquantel (a synthetic isoquinoline-pyrazine derivative endoparasiticide).
NexGard COMBO is indicated for:
- the treatment and control of flea (Ctenocephalides felis) infestations by killing adult fleas,
- the treatment and control of Ixodes scapularis (Blacklegged Ticks) and Amblyomma americanum (Lone Star Ticks),
 -the treatment of ear mites (Otodectes cynotis),
 -the prevention of heartworm disease (Dirofilaria immitis),
 -the treatment and control of intestinal cestode infections caused by the adult tapeworms Dipylidium caninum and Echinococcus multilocularis
 -the treatment and control of intestinal nematode infections caused by adult Toxocara cati; in cats and kittens 8 weeks of age and older.